Response to Effect of serum chloride on mortality in hypertensive patients.

نویسندگان

  • Linsay McCallum
  • Panniyammakal Jeemon
  • Claire E Hastie
  • Rajan K Patel
  • Catherine Williamson
  • Adyani Md Redzuan
  • Jesse Dawson
  • William Sloan
  • Scott Muir
  • David Morrison
  • Gordon T McInnes
  • Ellen Marie Freel
  • Matthew Walters
  • Anna F Dominiczak
  • Naveed Sattar
  • Sandosh Padmanabhan
چکیده

Response to Effect of Serum Chloride on Mortality in Hypertensive Patients We thank Kawada for the comments1 on our article.2 We recognize the importance of lipids in outcomes. We had only baseline total cholesterol available in a subset of patients, and it was not associated with either all-cause or cardiovascular mortality. Furthermore, incorporation of baseline total cholesterol in the model did not change the association between serum chloride and mortality. This may reflect the fact that patients with high cholesterol would be actively treated during follow-up. We do not have complete and accurate statin prescription data in all our patients to explore this further. Studying the individual effect of antihypertensive medications is beyond the scope of our observational data set with no measures of adherence or persistence of treatment. We believe follow-up blood pressure is the best measure of antihypertensive effect. Finally, we point out that we studied stroke mortality rather than incident stroke, and hence we do not have the data to speculate on different underlying mechanisms. We would encourage Kawada to study the association of serum chloride with outcomes in the Japanese population as the first step in validating this finding in other ethnic groups.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Improvement of common carp (Cyprinus carpio) fingerlings resistance to salinity stress with dietary safflower (Carthamus tinctorius L) extract supplementation

In this study, the effect of dietary safflower extract supplementation was investigated on common carp survival and physiological response to salinity stress. To this, the fingerling fish with average weight of 9.51 ± 0/13 g were fed with diets containing 0, 0.5, 1.5 and 3 % safflower extract for 70 days. After this period, some fish were randomly exposed to water salinity of 20 g/l and their m...

متن کامل

Effect of regular aquatic exercises on blood pressure in Hypertensive subjects: a meta-analysis

There is a large necessity for met analytic investigation of the blood pressure (BP) response to aquatic exercise training (AET) in hypertensive patients. was to quantify BP changes after (AET) and identify subgroups exhibiting the largest changes. Clinical trials investigating the impact of AET on hypertensive patients published in English and Persian research journals up to July 2020 were sea...

متن کامل

Effect of serum chloride on mortality in hypertensive patients.

Effect of Serum Chloride on Mortality in Hypertensive Patients To the Editor: I have read with interest the large and long follow-up study by McCallum et al1 concerning the risk of low serum chloride on the mortality in 12 968 patients with hypertension. They concluded that an increase of the serum chloride by 1 mEq/L was associated with a 1.5% reduction of the all-cause mortality, cardiovascul...

متن کامل

The Effect of Opium Addiction on Response to Major Operation Stress

Background: Internal medicine consultants are frequently asked to evaluate patients' tolerance against the stress of an intended surgical operation. Classification of surgical operations to mild, moderate and major is based on the morbidity and mortality rates due to the procedure, duration of procedure and underlying risk factors of the patient. Body response to surgical stress is via some hor...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Hypertension

دوره 63 3  شماره 

صفحات  -

تاریخ انتشار 2014